爱丽丝(米拉·乔沃维奇 Milla Jovovich 饰)重回在东京,向安布雷拉公司复仇。后者潜藏在地球的底部,威斯克(肖恩·罗伯茨 Shawn Roberts 饰)执行着自以为是的安 全技术标准。爱丽丝闯入了禁区,直捣黄龙。而威斯克竟然不惜毁灭城市做困兽斗。最终,当他驾驶着直升机逃离时,却被爱丽丝胁迫,情急之下,他向爱丽丝身上注入了具有对T细胞的免疫病毒,令她丧失了超能力,只能驾机飞翔荒无人烟的阿拉斯加。地球上已经177天没有生命迹象。然而,爱丽丝却意外发现了克莱尔(艾丽·拉特 Ali Larter 饰)。她们循着阿卡迪亚信号,回到了地狱之城,满眼的僵尸令人触目惊心。迎接她们的是同样听到信号的幸存者。在神秘犯人克里斯(文特沃斯·米勒 Wentworth Miller 饰)的帮助下,她们向阿卡迪亚之船进发……
In a small, remote village in upstate Quebec, things have changed. Locals are not the same anymore - their bodies are breaking down and they developed an outlandish attraction for flesh.
On a weekend getaway at a rundown cabin in the woods, Jason, a cautious teen, his crude best friend Colin and his fearless older sister Summer are forced to work together, grow up and save their hard partying parents from their predatory neighbour (Lauren Holly) who is intent on feeding them all to her undead family…
The dead are coming back to life outside the isolated Mi'gMaq reserve of Red Crow, except for its Indigenous inhabitants who are strangely immune to the zombie plague.